Maria was the first female comic to have two half-hour Comedy Central Presents specials and starred alongside Patton Oswalt, Zach Galifianakis and Brian Posehn in The Comedians of Comedy. She also created and starred in the cult hit web series The Maria Bamford Show, in which she plays all the characters.

Maria is often recognized for her prolific voiceover work, including characters on Big Mouth and its spinoff Human Resources, HouseBroken, Teenage Euthanasia, Santa, Inc., Bob’s Burgers, Bojack Horseman, Summer Camp Island, Adventure Time, Talking Tom and Friends, Legend of Korra, Puss in Boots, CatDog and PBS’s Emmy-winning series Word Girl. She played DeBrie Bardeaux on Netflix’s
Arrested Development and recurred on the ABC hit series Fresh off the Boat. Other TV guest roles include Night Court, Life & Beth, Portlandia, Kenan, Mr. Mayor, and large recurring roles on Hulu’s Everything’s Gonna Be Okay, and Showtime’s Flatbush Misdeameanors. Maria was also Emmy-nominated for her guest appearance on the Netflix children’s series Ask the StoryBots.

Maria’s late-night appearances include The Late Show with Stephen Colbert, Late Night with Seth Meyers, CONAN, The Late Late Show with James Corden and The Tonight Show. Her interview series What’s Your Ailment? deals with the various mental struggles of celebrities and is available on the Topic streaming service. Her Audible Original You Are (A Comedy) Special is a semi-mock
instructional book for both standup and life.